Publications
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FANCA-dependent FEN1 recruitment suppresses transcription-replication conflicts and PARPi sensitivity
Molecular Cell · 2026
Qinhong Wang, Simon W. Ellington, Paolo Guerra, Faeze Gharibpoor, Dennis A. Simpson, Min-Guk Cho, Adriana Beltran, Gaorav P. Gupta
DOI: 10.1016/j.molcel.2026.05.027 - PMID:
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DOI: 10.1016/j.molcel.2026.05.027 - PMID:
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Molecular mechanisms regulating cGAS/STING activation in health and disease
Journal of Clinical Investigation · 2026
Cdk1-dependent lamin aggregation underlies oxidative stress-induced nuclear shape abnormalities
BMB Reports · 2026
Ju-Hyun Ahn, Min-Guk Cho, Abdul Basit, In-Kang Song, Kong-Joo Lee, Jae-Ho Lee
DOI: 10.5483/bmbrep.2024-0164 - PMID:
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DOI: 10.5483/bmbrep.2024-0164 - PMID:
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FANCA Deficiency Induces Oncogenic R-Loop Dependent Synthetic Lethality with PARP1 Inhibitors
· 2025
Gaorav Gupta, Qinhong Wang, Simon Ellington, Paolo Guerra, Faeze Gharibpoor, Dennis Simpson, Min-Guk Cho, Adriana Beltran
DOI: 10.21203/rs.3.rs-6080272/v1 - PMID:
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DOI: 10.21203/rs.3.rs-6080272/v1 - PMID:
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Unveiling cGAS mechanisms: Insights into DNA damage and immune sensing in cancer
DNA Repair · 2025
Mechanisms of Immune Sensing of DNA Damage
Journal of Molecular Biology · 2024
Anna M. Goddard, Min-Guk Cho, Lynn M. Lerner, Gaorav P. Gupta
DOI: 10.1016/j.jmb.2023.168424 - PMID:
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DOI: 10.1016/j.jmb.2023.168424 - PMID:
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MRE11 liberates cGAS from nucleosome sequestration during tumorigenesis
Nature · 2024
Min-Guk Cho, Rashmi J. Kumar, Chien-Chu Lin, Joshua A. Boyer, Jamshaid A. Shahir, Katerina Fagan-Solis, Dennis A. Simpson, Cheng Fan, Christine E. Foster, Anna M. Goddard, Lynn M. Lerner, Simon W. Ellington, Qinhong Wang, Ying Wang, Alice Y. Ho, Pengda Liu, Charles M. Perou, Qi Zhang, Robert K. McGinty, Jeremy E. Purvis, Gaorav P. Gupta
DOI: 10.1038/s41586-023-06889-6 - PMID:
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DOI: 10.1038/s41586-023-06889-6 - PMID:
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TPX2 Amplification-Driven Aberrant Mitosis in Culture Adapted Human Embryonic Stem Cells With Gain of 20q11.21
Stem Cell Reviews and Reports · 2021
Ho-Chang Jeong, Young-Hyun Go, Joong-Gon Shin, Yun-Jeong Kim, Min-Guk Cho, Dasom Gwon, Hyun Sub Cheong, Haeseung Lee, Jae-Ho Lee, Chang-Young Jang, Hyoung Doo Shin, Hyuk-Jin Cha
DOI: 10.21203/rs.3.rs-982680/v1 - PMID:
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DOI: 10.21203/rs.3.rs-982680/v1 - PMID:
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Dual inhibition of DNA-PK and DNA polymerase theta overcomes radiation resistance induced by p53 deficiency
NAR Cancer · 2020
Rashmi J Kumar, Hui Xiao Chao, Dennis A Simpson, Wanjuan Feng, Min-Guk Cho, Victoria R Roberts, Aurora R Sullivan, Sonam J Shah, Anne-Sophie Wozny, Katerina Fagan-Solis, Sunil Kumar, Adam Luthman, Dale A Ramsden, Jeremy E Purvis, Gaorav P Gupta
DOI: 10.1093/narcan/zcaa038 - PMID:
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DOI: 10.1093/narcan/zcaa038 - PMID:
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The cGAS/STING/TBK1/IRF3 innate immunity pathway maintains chromosomal stability through regulation of p21 levels
Experimental & Molecular Medicine · 2020
Abdul Basit, Min-Guk Cho, Eui-Yun Kim, Dohyeong Kwon, Suk-Jo Kang, Jae-Ho Lee
DOI: 10.1038/s12276-020-0416-y - PMID:
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DOI: 10.1038/s12276-020-0416-y - PMID:
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MED28 Over-Expression Shortens the Cell Cycle and Induces Genomic Instability
International Journal of Molecular Sciences · 2019
Jin Gu Cho, Joon-Seok Choi, Jae-Ho Lee, Min-Guk Cho, Hong-Sook Kim, Hee-Dong Noh, Key-Hwan Lim, Byoungjun Park, Jin-Ock Kim, Sang Gyu Park
DOI: 10.3390/ijms20071746 - PMID:
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DOI: 10.3390/ijms20071746 - PMID:
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Inhibition of PP2A activity by H2O2 during mitosis disrupts nuclear envelope reassembly and alters nuclear shape
Experimental & Molecular Medicine · 2019
Ju-Hyun Ahn, Min-Guk Cho, Seonghyang Sohn, Jae-Ho Lee
DOI: 10.1038/s12276-019-0260-0 - PMID:
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DOI: 10.1038/s12276-019-0260-0 - PMID:
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ATP depletion during mitotic arrest induces mitotic slippage and APC/CCdh1-dependent cyclin B1 degradation
Experimental & Molecular Medicine · 2018
DNA double-strand breaks and Aurora B mislocalization induced by exposure of early mitotic cells to H2O2 appear to increase chromatin bridges and resultant cytokinesis failure
Free Radical Biology and Medicine · 2017
Min-Guk Cho, Ju-Hyun Ahn, Hee-Song Choi, Jae-Ho Lee
DOI: 10.1016/j.freeradbiomed.2017.03.025 - PMID:
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DOI: 10.1016/j.freeradbiomed.2017.03.025 - PMID:
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A putative pH-dependent nuclear localization signal in the juxtamembrane region of c-Met
Experimental & Molecular Medicine · 2014
Shubhash Chandra Chaudhary, Min-Guk Cho, Tuyet Thi Nguyen, Kyu-Sang Park, Myung-Hee Kwon, Jae-Ho Lee
DOI: 10.1038/emm.2014.67 - PMID:
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DOI: 10.1038/emm.2014.67 - PMID:
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